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BREZIS, M., ROSEN, D., SILVA, P., & EPSTEIN, F.H

Paying more per milligram for an injectable that has documented IP-route preclinical data may be the better cost-per-effective-mg trade than paying less per milligram for a route with no published systemic exposure data in humans

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For example, the increased dosage of CBS and GCS in our simulation of Down syndrome causes the intracellular concentration of cysteine to decline while the blood concentration increases

The NLRP3 inflammasome promotes the release of pro-inflammatory cytokines such as IL-18, which activate NK cells and CD4 + T cells, thereby strengthening immune responses and protecting epithelial cells from damage [87, 87]