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These compounds demonstrate potential as standalone therapies, and also in combination with conventional treatments like sorafenib by enhancing the effectiveness and overcoming resistance

Side effects can include pain or redness at the injection site, mild diarrhea, itching, or a feeling of swelling all over the body

NNMT-mediated SAM depletion can alter cell MP, contributing to the change in global epigenetic histone profiles in cancer (7, 93)

Western Blot Analysis Cell extracts were prepared in lysis buffer containing Tris-HCl, pH 7.5, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 2 mM PMSF and 1% Triton X-100 followed by ultrasonication method

Angiogenesis and chronic inflammation: Cause or consequence