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MSC derived from umbilical cord, adipose and bone marrow are commonly used for OA treatment, as they exhibited active immunosuppressive properties, capacity for chondrocyte differentiation, high proliferation potential and stability without undergoing dedifferentiation [110]

Future studies should delve deeper into these mechanisms, develop more effective diagnostic methods, and create personalized treatment plans to improve patient outcomes

Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin

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