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A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

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Edmunds, L., Elswood, J., Kennedy, L

Nature 526 , 660665 (2015)

Access this chapter Similar content being viewed by others Abbreviations -KG: -Ketoglutarate 2HG: 2-Hydroxyglutaric acid ASS: Argininosuccinate synthetase ECG: Epicatechin gallate EGCG: Epigallocatechin gallate ETC: Electron transport chain FDG-PET: Fluorodeoxyglucose-positron emission tomography FH: Fumarate hydratase GBM: Glioblastoma multiforme GDH: Glutamate dehydrogenase GLS: Glutaminase GOT: Glutamic-oxaloacetic transaminase GPT: Glutamic-pyruvate transaminase HIF: Hypoxia-inducible factor IDH: Isocitrate dehydrogenase IDO: Indoleamine-2,3-dioxygenase PEG: Poly(ethylene glycol) PHD: Prolyl 4-hydroxylases PLGA: Poly(lactic-co-glycolic acid) PSAT: Phosphoserine aminotransferase RCC: Renal cell carcinomas SDH: Succinate dehydrogenase SHMT: Serine hydroxymethyltransferase TCA: Tricarboxylic acid TDO: Tryptophan-2,3-dioxygenase References Chen, J