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As shown in Figure 6A , GSH levels decreased to 2540% of control cells after AQ-QI or DEAQ-QI treatment, while the intracellular GSSG concentrations did not increase correspondingly, but decreased to approximately 4580% ( Figure 6B )

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These effects are partly attributed to an endothelium-dependent vasodilator effect, primarily through activation of the eNOS-NO-soluble guanylyl cyclase (sGC) pathway, along with reductions in HR and CCB activity