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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Methylcobalamin is a source of vitamin B12 that is highly absorbable

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The inactivation of cytAspAT by -chloro-l-alanine, however, can be decreased by inclusion in the reaction mixture of a Michael acceptor such as thiosulfate (Cavallini et al., 1973) or -mercaptoethanol (Adams et al., 2005)