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Eur J Pharmacol 15(771):211219 Belosic Halle Z, Vlainic J, Drmic D, Strinic D, Luetic K, Sucic M et al (2017) Class side effects: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine antagonists, neuroleptics, anti-emetics, L-NAME, pentadecapeptide BPC 157 and L-arginine

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This creates a challenging bottleneck for formulators who need to deliver a functional dose to achieve the desired output

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Bicyclic Peptides and CLIPS Cyclization Technology Peptides that contain two macrocyclic structures are commonly referred to as bicyclic peptides