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Constant, whole-brain-traversing rostro-caudal gradients (resulting from monotonically increasing modes) are rarely reported in the literature, likely because most brain organization follows more complex, multidirectional patterns and is typically confined to specific brain systems, such as the principal morphometric similarity mode separating motor from sensory cortices 56 , the developmental and evolutionary cortical expansion where association cortices enlarge most relative to primary areas 57 , or the microstructural sensory-fugal gradient that extends from sensory anchors toward transmodal cortex 58

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TB-500 is a synthetic analog of thymosin beta-4 (TB4) , a protein found in most human and animal cells