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Research has confirmed that MET inhibitors such as capmatinib and tivantinib can maintain the stability of PD-L1 expression by inhibiting GSK3-driven phosphorylation and the subsequent breakdown of PD-L1

It is typically administered once a week via injection and is considered safe for extended use, especially in the context of chronic conditions like obesity and diabetes

Early data also suggest its benefits for lowering cholesterol levels, liver fat reduction, and cardiovascular health protection

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