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Genistein, a broad spectrum tyrosine kinase inhibitor, inhibits hDOR desensitization promoted by DPDPE, deltorphin I, and etorphine (Marie et al., The major role of DOR phosphorylation at S363 was confirmed using the mutant receptor S363A

Wang, S., Liu, Z., Geng, J., Li, L

Integrating these important observations within the theoretical framework of this review may provide the impetus to clearly establish the clinical significance of these intriguing concepts and the potential inherent in this field supports further investment and concerted efforts in this area

The study also confirmed that exercise induces endogenous MOTS-c production in human skeletal muscle, establishing a bidirectional relationship between MOTS-c and physical activity (Reynolds JC et al., Nat Commun

al., 2025