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SIRT1 deacetylates histones and transcription factors like p53 and NF-B to regulate gene expression

Insufficient selenium intake reduces phagocytic selenium level, which can reduce oxidative burst as seen in the neutrophils from selenium-deficient rats [67]

J Agric Food Chem 70(40):1295312967 Zhao T, Yu Z, Zhou L, Wang X, Hui Y, Mao L, Fan X et al (2022c) Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice

The results were striking: Obese mice fed a high-fat diet and treated with the mTOR inhibitor rapamycin lost significant amounts of weight, whichsimilar to leptin treatment in leptin-sensitive animalswas primarily due to a decrease in the amount of adipose tissue, Tan says