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As fasting increases ketone production with a concomitant increase in CYP2E1 activity, this in turn increases the production of NAPQI and decreases amino acid substrates for GSH production

10.1111/jdi.12376 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang Y., Wu H., Dong N., Su X., Duan M., Wei Y., et al

Despite the BBB acting as a restrictive barrier, endothelial cells participate in mediating inflammation in the brain by communicating immunological signals to perivascular Ms and neighboring microglia, which can extend to parenchymal cells

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After 10 ns, the system reached stability