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Description
Optimal antioxidant defense and immunological functions are inherently linked to oxidative metabolism as sirtuins 1 (Sirt-1) and sirtuins 3 (Sirt-3) depend on NAD + as a substrate for their deacylation activity
Beyond SREBP1, mTORC1 also regulates lipogenesis by activating SREBP2, thereby upregulating 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), a key enzyme in the cholesterol synthesis pathway [132, 133]
doi: 10.3389/fnut.2024.1355542 242 YangZMaoWWangJYinL
So they switched them onto the next approach
Verkhratsky et al., 2014)
