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1,13 Fibromyalgia pain is widespread, occurring in nearly any region of the body, though specific areas such as the back or neck may be particularly painful in some individuals

From a mechanistic perspective, the contraction of muscle fibers and the hemodynamic forces elicited by exercise activate a complex network of intracellular signaling pathways which collectively enhance mitochondrial biogenesis and quality control, stimulate angiogenic processes, and augment eNOS activity along with NO production (73, 74)

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doi: 10.3390/nu14235103
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Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2
