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Do not apply to broken or irritated skin

Statins work competitively by hindering HMG-CoA reductase and lowering liver cholesterol synthesis (Wassmann et al., 2002)

Obese mice that were trained on a motorized treadmill for 45 min per day 5 days a week for 12 weeks had higher expression levels of colonic ZO-1 and occludin

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Similarly, this is also seen in the setting of many chronic diseases such as metabolic syndrome and diabetes [3,4], atherosclerosis and cardiovascular disease [5], chronic kidney disease [6], neurodegenerative conditions such as Alzheimers disease and Parkinsons disease [7-9], as well as autoimmune diseases [10], cancer [11] and chronic infections such as human immunodeficiency virus [12]