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Furthermore, the A118G polymorphism has shown an increase in responsiveness to naltrexone in humans with alcohol dependence, as well as an decrease in buprenorphine efficacy in a murine model of OPRM1 A118G (Chamorro et al., 2012

10.1016/j.tox.2018.01.007 95 YangR.SongC.ChenJ.ZhouL.JiangX.CaoX.et al (2020)

doi: 10.1016/j.ejphar.2011.05.038
