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Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

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The calcium-independent phospholipase iPLA2b is sufficient to detoxify the peroxidized lipids to suppress p53-driven ferroptosis upon ROS-induced stress [71]

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