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Statements Author contributions WX: Writing review & editing, Writing original draft, Conceptualization

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Inflammopharmacology 14:214221 Wood JD (2004) The first Nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904

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This, in turn, especially at extremely high concentrations, has been noticed to induce modifications of different molecules, including DNA [159] and proteins [160], which ultimately can be one of the major contributors in the pathogenesis of various neurodegenerative diseases [161]

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