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Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms
10.1080/09546630310019346 [DOI] [PubMed] [Google Scholar] 8.Mrowietz U, Szepietowski JC, Loewe R, van de Kerkhof P, Lamarca R, Ocker WG, et al

One cup of shiitake mushrooms provides approximately 0.1 micrograms of B12

Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease

In press Singh AK, Firdaus Z, Prakash P, Singh R, Nandy N, Bansal M, Singh RK, Srivastava A, Roy JK, Mishra B, Singh RK (2017) Curcumin quantum dots mediated degradation of bacterial biofilms