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There has been some research on the potential of plant-based foods as a source of lipotropes

Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4

Medication is one piece of the picture
