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82,83 GPX1 is shown to promote proinammatory cytokine production and neutrophilia in response to endotoxin, 84 and to contribute to the development of ovalbumin-induced allergic asthma

(W-02074A): Beaver Dam Water Company, Inc

Morales-Villegas EC, Yarleque C, Almeida ML

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists