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In lung adenocarcinoma (LUAD) cells, the E3 ligase MIB1 was shown to induce ubiquitination of Nrf2 in the Neh2 structural domain, following which the ubiquitinated Nrf2 was degraded via the proteasomal pathway

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However, this study did not look at specific fractions within the serum and liver specific signals were not dissected 30
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