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Most individuals see effective results with 1,000 mg to 2,000 mg of L-carnitine per day

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RM-718, PL7737 and 710GO all report efficacy with acceptable nonclinical safety profiles, including no evidence of cardiac activation ( Incretins, the current standard of care for obesity, have drawbacks including GI-side effects, rebound after cessation of treatment, and lean mass loss ( While current clinical candidates focus primarily on selective MC4R agonism for the limited treatment of genetic and hypothalamic obesity, 710GO appears to be the only current developmental program poised to address general obesity as a monotherapy
