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Available at: Ethics statement The animal study was approved by the Institute of Infection and Immunology, Chinese Academy of Sciences for the Care and Use of Laboratory Animals with the approval of the Institute Animal Welfare, and Care Committee with No

238 Inhibiting the demethylase activity of FTO with Rhein can sensitize resistant cells to TKIs, downregulate Bcl-2 and MER proto-oncogene, tyrosine kinase (MERTK), thus regulating the PI3K-AKT-mTOR pathway and the Bcl-2 family of proteins, which affects the invasion and apoptosis of cancer cells

doi: 10.1155/2021/5555315 67 LeeNRKimSBHeoHLeeYH

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway

J Physio