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Converting tanshinone IIA into its sodium sulfonate form (sodium tanshinone IIA sulfonate, STS) greatly increases polarity and bioavailability, and indeed STS is used interchangeably with tanshinone IIA in studies and has been approved in China as an injectable drug (Shao et al., 2024

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However, its activity has been minimal when used as alone ( Nimotuzumab is another anti-EGFR monoclonal antibody that has shown some promise, particularly when combined with radiation or TMZ chemoradiation

A high increase in F V /Fm ratios significantly increased the photosynthetically active radiation (PAR) values, reflecting high photosynthetic efficiency in the absence of YMV disease in the spring season