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In cytokine-stimulated astrocytes, arginine deprivation activates the amino acid-sensing kinase GCN2, leading to phosphorylation of eukaryotic initiation factor 2 (eIF2) and suppression of iNOS protein synthesis, thereby attenuating NO production

The Jarisch-Herxheimer reaction was first identified by two dermatologists, Adolf Jarisch and Karl Herxheimer, while studying syphilis

Yes, melasma can be managed with treatments like topical lightening agents, chemical peels, laser therapy, and strict sun protection

10.3389/fphar.2022.1026182 TABLE 10 Structures of six metabolites identied by high-performance liquid chromatography-tandem mass spectrometry in rat plasma, bile, urine, and feces following a single intramuscular administration of 100 g/300 Ci/kg of [3H]BPC157

10.1016/j.devcel.2012.02.011 16 ChuY.-M.WangT.-X.JiaX.-F.YangY.ShiZ