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GPX3 mRNA is expressed in the kidney, pancreas, lung, breast, brain and gastrointestinal tract, but the majority of GPX3 is expressed in the plasma which is kidney-derived

S., Santos, G

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

Unlike disorders driven primarily by protein aggregation at the organelle level, HD is fundamentally a disease of profound systemic metabolic reprogramming initiated by early nuclear transcriptional dysregulation

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