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doi: 10.1097/JGP.0b013e31817c6aab, 49
Unfolding the cristae helps the matrix to expand and the IMM remains intact
We showed that senescent cells are primed for ferroptosis and that targeting GPX4 unlocks a vulnerability of senescent cells that can be exploited for therapeutic benefit
GPx is a selenoprotein that reduces lipidic or nonlipidic hydroperoxides as well as H 2 O 2 utilizing glutathione [55]
In the presence of oxygen, these unstable free radicals quickly form PUFA peroxyl radicals, which ultimately convert into PUFA hydroperoxides
