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Differential Effects of Itaconate and Its Esters on the Glutathione and Glucose Metabolism of Cultured Primary Rat Astrocytes. Neurochemical Research 50: 24
These results appear to contradict finding reported in vivo (Payabvash et al., 2006)

One is by up-regulating a signaling protein called VEGF (vascular endothelial growth factor), which encourages the growth of new capillaries

Meng G, Chai K, Li X, Zhu Y, Huang W (2016) Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway

Metabolism serves to convert these hydrophobic chemicals into more hydrophilic derivatives that can easily be eliminated from the body through the urine or the bile
