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In a recent clinical trial, people with celiac disease received either TAK-101 or a saline placebo intravenously and then ingested gluten (20)

Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20

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For pediatric patients, we recommend focusing on foundational health strategies such as proper nutrition, gut support, and lifestyle modifications to promote overall well-being