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Further studies are necessary to look for a possible relation between xenobiotic exposures and the deregulation of miRNA expression involved in neurodegeneration

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Subsequently, the study found that reducing the plasma LEAP2/ghrelin ratio reversed cognitive deficits in aged mice by restoring hippocampal neurogenesis, alleviating synaptic loss, and inhibiting neuroinflammation

Wanglin Dong: Writing review & editing

Tumor necrosis factor (TNF) similarly impairs ABCA1-mediated efflux and sterol-O-acyltransferase 1 (SOAT1)-dependent cholesterol esterification through an NFATc1-dependent mechanism, promoting apoptosis (65)