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6 Conclusion Oxidative stress, defined as an imbalance between the production of reactive oxygen species ROS and antioxidant defenses, plays a pivotal role in the pathogenesis of major diseases, including cardiovascular disorders, diabetes, cancer, and neurodegenerative conditions

It reflects the pharmacological action of the medication working as designed

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Thus, the site of GluN2C expression together with its unique biophysical properties (lower Mg 2+ -block, lack of desensitization and high agonist affinity) 17 , suggest that GluN2C-containing receptors may have significant impact on cortical function

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