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Biochimica et Biophisica Acta

Methylfolate supports healthy methylation and bypasses the MTHFR mutation, while folinic acid supports DNA production, repair, and neurotransmitter formation

For instance, acetylation of lysine residues on histones H3 and H4 is associated with gene activation, while methylation can either activate or repress gene expression depending on the site and degree of modification
Katto et al
Henderson CJ, Smith AG, Ure J, Brown K, Bacon EJ, Wolf CR