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The final step of BH 4 synthesis actually involves three distinct steps all of which are catalyzed by the NADPH-dependent enzyme, sepiapterin reductase (SR)

Control mice were homozygous for the loxP-flanked Ghr allele, whereas their littermates carrying the Cre alleles were considered the conditional knockout mice

[5] Green H, et al

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Development of curcumin liposome formulations using polyol dilution method
