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Endocrinol Metab Clin North Am 2012;41(3):527-556

B12 supplement (cyanocobalamin) vs natural B12 (methylcobalamin) A study conducted in Los Angeles, California, presented evidence stating all forms of vitamin B12 in food and supplements are reduced to a common cobalamin molecule, which is then transformed into two active forms in cells, methylcobalamin and adenosyl cobalamin [14]