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Metformin inhibits mitochondrial complexes in the electron transport chain, leading to decreased aerobic metabolism and a subsequent increase in lactate production

J Clin Oncol 2002

Salem ME, Kopetz S , El-Refai SM, Tabernero J, Sinicrope FA, Tie J, George TJ, VanCutsem E, Mauer E, Lonardi S, Andre T, Overman MJ, Foureau D
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Hja L, Nyitrai G, Kkesi O et al (2012) Astrocytes convert network excitation to tonic inhibition of neurons
