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Cognitive symptoms may result from multiple mechanisms, including infection, inflammation, sleep disturbance, autonomic dysfunction, medication effects, co-infections, or other medical conditions

DixonSLembergKLamprechtMSkoutaRZaitsevEGleasonCet alFerroptosis: an iron-dependent form of nonapoptotic cell death

Cells were incubated with 200 nM MitoTracker in the dark at 37C for a duration of 15 min

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At the cellular level, ferroptosis is triggered by the inhibition of cell membrane translocation factors such as cystine/glutamate translocator (also known as the system Xc-) or the activation of transferrins, as well as the blockade of intracellular antioxidant enzymes such as glutathione peroxidase 4 (GPX4) (3, 9)