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In addition to these biological factors, there are many methodological problems

Autoimmunity reviews , 8 (8), 697-701

There have been numerous hypotheses about the topographical units that is affected in ME/CFS, which variably invoked the locus coeruleus, the amygdala, the paraventricular nucleus, the suprachiasmatic nucleus or the vagal centers of the brainstem

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Ferroptosis is also closely associated with inflammation, mitochondrial dysfunction, and the gut microbiota, which also play important roles in AS and depression
