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This review briefly discusses the endogenous (mitochondria, NADPH, xanthine oxidase (XO), Fenton reaction) and exogenous (e.g., smoking, radiation, drugs, pollution) sources of ROS (superoxide radical, hydrogen peroxide, hydroxyl radical, peroxyl radical, hypochlorous acid, peroxynitrite)

Figure 4 Phosphorylation at Serine-184 of GSTP Is Crucial for Its Nuclear Translocation and Interaction with HMGB1 Protein post-translational modifications, such as phosphorylation is closely related with protein subcellular location (50)

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Phase Early escalation Weeks 5-8 Weekly Dose 4 mg Notes Step up every 4 weeks