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The Plant Cell 27, 17551770

Substitution of three aromatic residues with threonine (W385T), tyrosine (F417Y), and alanine (W525A), present at the corresponding positions in EcGGT, resulted in enhanced transpeptidase activity for all three mutants, while a 514% decrease in hydrolytic activity was observed

Chronically, hypoxic cells will only become reoxygenated when their distance from the lumen of a blood vessel decreases, such as during fractionated radiotherapy when tumor cords shrink

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The parent compound may be undetectable within hours