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In the absence of targeted pharmacological interventions for specific aldehyde types, the core of any treatment plan necessitates the continuous use of one or more strong sulfur-containing antioxidants, such as NAC, taurine, GSH, and lipoic acid, to react with and neutralize the accumulated aldehydes before additional cellular damage occurs

Nat Cell Biol 3: 874882 Shi ZZ, OseiFrimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW (2000) Glutathione synthesis is essential for mouse development but not for cell growth in culture

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Delivery of siRNA silencing P-gp in peptide-functionalized nanoparticles causes efflux modulation at the blood-brain barrier