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One notable dual-substrate NNMT inhibitor is Yuanhuadine, which is isolated from the flower buds of the traditional Chinese medicine Daphne genkwa
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PMID: 27304506
Bottom line: Its almost impossible to become toxic on vitamin B12 unless you have kidney issues
In studies, injections of certain prescription medications reduced obese participants body weight by up to 30%, but it took 72 weeks for that amount of weight loss to happen
