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For example, in the case of HIV, IgG3 has been shown to be generally more effective at neutralization than IgG1 of the same specificity, possibly related to the greater flexibility of IgG3 associated with a longer hinge region, which allows for more restricted epitopes to be accessed, although there are some exceptions 97,98,99,100

903 In a RANKL-induced osteoclast model, the bisphosphonate zoledronic acid promotes ferroptosis by increasing Fe 2+ , ROS, and MDA levels, and decreasing GPX4 and GSH levels

Buglio D, Schober W, Contractor R, McQueen T, Zeng Z, Kantarjian H, Weiser MA, Andreeff M , Konopleva M