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Conversely, VRK2-low PC cells exhibit impaired SLC7A11 membrane localization and intrinsic oxidative stress, creating a therapeutic window for GSH inhibition

Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

Each plays a distinct role

C/EBP plays crucial roles in regulating genes implicated in organ development, immune and inflammatory responses, such as IL-6 expression, and macrophage differentiation (Portale et al., 2024)

Effects of dash diet on lipid profiles and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized clinical trial