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In addition, BHB inhibits NLRP3 activation, resulting in a reduced release of inflammatory factors, particularly IL-1 and IL-18, by inhibiting caspase-1 activation (176, 190)

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In previous studies that compared the differentiation capacity of chondrocytes from different passages, the results indicated that cells at early passages usually generated more cartilage matrix than those at late passages upon chondroinduction (Schulze-Tanzil et al., 2002