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Laboratory studies have also examined its proposed role in modulating gene expression, circadian and pineal regulatory pathways, oxidative-stress responses, and the development of spontaneous tumors in rodent models

In experiments with rats with CKD, skeletal muscles show decreased serum levels of IGF-1 and IGF-1 mRNA, while IGF-1R mRNA and IGF-1R numbers are increased, with normal binding affinity

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