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Thus, these results suggest that pancreatic cancer cells carrying both KRAS and p53 mutations are vulnerable to BSO and DPI combinatory inhibition, and the cytotoxic effect of BSO and DPI was mainly triggered by a redox-mediated mechanism

7 SSP inhibition suppresses de novo serine biosynthesis

Ninety-five percent of the dietary glutamate is metabolized by intestinal cells in a first pass