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Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM: Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
IGF-1R has been implicated in several different types of cancer include breast, prostate, and lung cancer

In conclusion, lipid peroxidation-induced muscle cell death and atrophy are key factors in the development of sarcopenia
Hepatic dysfunction critically contributes to metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and fibrotic progression (13,15)

Semin Neurol 2013;33:297306
