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It has been shown to promote healing by resolving vessel constriction, stabilizing the primary platelet plug, and resolving the clot

These effects were reported to be maintained over several weeks, often after a single administration, although anecdotal reports and a pilot study suggested additional improvements with repeated administration of perispinal etanercept treatment for stroke

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Its ability to cross the bloodbrain barrier in laboratory models, combined with a relatively long plasma half-life compared to other small neuropeptides, has contributed to its enduring relevance in neurochemistry research