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The lower availability of SAMe may be related to the altered expression of genes involved in APP metabolism, finally producing the accumulation of A peptide, contributing to the pathological processing of AD [6, 140]

However, it is important to note that prolonged use of JHU083, while inhibiting glutamine metabolism, has been shown to lead to the upregulation of accumulated reactive oxygen species

It also helps to maintain the antioxidant activity of Vitamin C & E

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